Sale Sharks centre Evie Wills replaces the injured Emma Orr as Scotland make just one change from their win over Wales as England visit Murrayfield on Saturday.
Highly regarded Trailfinders wing Fran McGhie is only considered fit enough for the bench on her return from injury.
That means Shona Campbell continues on the left flank for the Six Nations match in Edinburgh.
It had already been announced that influential Bristol Bears centre Orr will miss the rest of the Six Nations after picking up a knee injury in the 24-19 win in Cardiff.
Scotland head coach Sione Fukofuka called up Montpellier’s Holly McIntyre as a replacement, but she does not make the bench.
